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WHO calls for early diagnostic tests for Lassa fever

The Lassa fever virus is transmitted to humans from direct contact with infected rats through catching and preparing them for food. The Lassa fever virus is transmitted to humans from direct contact with infected rats through catching and preparing them for food.

 1 April 2016 - Lassa fever has killed more than 160 people in West Africa, most of them in Nigeria, since November 2015. Many of these lives could have been saved if a rapid diagnostic test were available so that people could receive treatment early.

Since November 2015, Nigeria, Benin, Sierra Leone, Liberia and Togo have reported more than 300 cases of Lassa fever and 167 deaths. Nigeria accounts for the majority of the cases with 266 cases and 138 deaths reported in 22 of the country’s 36 states as at 21 March 2016. Benin has recorded 51 cases and 25 deaths. Togo and Sierra Leone each reported 2 cases. More recently, since February, Liberia has reported seven confirmed cases including 3 deaths.
Diagnosing Lassa fever a difficult task

Lassa virus is carried by the Mastomys rat, which is found in parts of West Africa. The virus is transmitted to humans from direct contact with infected rats by catching and preparing them for food, or through contact with food or household items contaminated with rat faeces or urine. The virus can also be transmitted through contact with an infected person’s body fluids.

Around 80% of people who become infected with Lassa virus have no symptoms or they have symptoms that mimic other illnesses, such as malaria, making it difficult to treat them. Symptoms include fever, fatigue, nausea, vomiting, diarrhoea, headaches, abdominal pains, sore throat and facial swelling.

“Without early diagnosis and treatment, 1 in 5 infections result in severe disease, where the virus affects several organs such as the liver, spleen and kidneys,” explains Dr Formenty, expert in haemorrhagic fevers at WHO.

“We need resources to invest in diagnostics to easily, accurately and safely test for Lassa fever as we do for malaria and HIV. Without a proper diagnosis, many people do not receive the correct treatment and that is why we see so many people with Lassa fever dying each year.”

Ribavirin has been used successfully in the treatment of confirmed Lassa cases. This drug can treat infected people if it is administered as soon as the first signs appear.
Germany reports first known Lassa infection outside Africa

The first known case of Lassa infection outside of Africa has been reported in Germany. One person, a funeral home employee was infected after direct contact with an American who died of the disease in February 2016. The American was a medical director of a missionary hospital in Togo who was evacuated to Germany where he died.

“This is the first time that secondary transmission of the infection is reported in Europe,” says Dr Formenty. “The risk for further transmission of Lassa fever in Germany and also West Africa is low and limited to hospital settings caring for the cases, with all contacts accounted for and monitored.”

WHO continues to monitor the epidemiological situation and conduct risk assessments based on the latest available information.
WHO and health partners scurry to stop the outbreak

WHO and partners, including United Nations Children's Emergency Fund (UNICEF), Center for Disease Control and Prevention (CDC) in Atlanta, Bernard-Nocht-Institute in Hamburg, Germany and humanitarian partners, are supporting national authorities in the affected countries to take emergency measures in response to the outbreak. These include:

  •     Setting up quarantine units in affected areas to isolate and treat patients.
  •     Creating contact tracing systems to find those who might have been exposed to the disease.
  •     Mobilizing a network of almost 200 community health workers across the country to monitor the contacts.
  •     Repositioning and providing Ribavirin, in affected areas, including distributing personal protection equipment and other medical supplies.
  •     Sharing information across borders.
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